The Effects of a AN69ST Membrane and Polysulphone Membrane on Septic Children With Continuous Blood Purification
Overview
- Phase
- Not Applicable
- Intervention
- blood purification(AN69ST)
- Conditions
- Sepsis
- Sponsor
- Children's Hospital of Fudan University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- organ injury changes
- Status
- Recruiting
- Last Updated
- 2 months ago
Overview
Brief Summary
In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality. For sepsis, blood purification can remove inflammatory factors in sepsis by filtration or adsorption, so as to achieve the purpose of reducing inflammatory mediators in the body. However, there are few prospective randomized controlled studies in children. Therefore, this study intends to compare the efficacy and prognosis of different membrane on children with sepsis through a perspective cohort study, so as to provide a corresponding basis for the treatment of children with sepsis blood purification.
Detailed Description
Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection. In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality. Blood purification therapy is gradually developed on the basis of renal replacement therapy, and now it is more and more widely used in the field of critical care in children. CVVH can reduce the level of inflammation in the body in different membranes, but the results of reducing inflammatory factors are different, and the outcomes of patients are also different. Blood purification treatment can reduce inflammatory mediators in sepsis, but there are few prospective randomized controlled studies in children. Therefore, this study intends to compare the efficacy and prognosis of different blood purification membrane in children with sepsis through a perspective cohort study. Provide the corresponding basis for blood purification treatment of the disease.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Meet the 2005 diagnostic criteria for sepsis
- •Age 29 days - 18 years old
- •Sepsis-induced dysfunction of more than one organ or abnormal tissue perfusion, or septic shock
- •Diagnosis \< 48 hours
Exclusion Criteria
- •Inability to obtain an informed consent from the subject, family member or an authorized surrogate
- •Subject has end-stage renal disease and requires chronic dialysis
- •There is clinical support for non-septic shock
- •Subject has had chest compressions as part of cardiopulmonary resuscitation this hospitalization without immediate return to communicative state
- •Subject has uncontrolled hemorrhage
- •Subject has immunodeficiency diseases
- •Subject has received chemoradiotherapy or immunosuppressive therapy in the 14 days before enrollment
- •HIV infection in association with a last known or suspected CD4 count of \<50/mm3
- •Subject has sustained extensive third-degree burns within the past 7 days
- •Subject has known sensitivity or allergy to heparin or has a history of heparin associated thrombocytopenia
Arms & Interventions
blood purification(AN69ST)
Intervention: blood purification(AN69ST)
blood purification(PS)
Intervention: blood purification(PS)
Outcomes
Primary Outcomes
organ injury changes
Time Frame: from enrollment to the 3th days
the difference of the organ injury changes would be measured at the 3th day after enrollment
cytokine change
Time Frame: from enrollment to the 3th days
This is a binary variable. It is also a compositional variable including IL-6, IL-10, TNF-a, IL-4, IL-2 and etc. If one of the factors changes, it is considered that the variable changes. If the cytokine drops below half of the original value, it is considered to be changed. The cytokine would be measured measured at the 7th day after enrollment
Secondary Outcomes
- survival rate(from enrollment to the 28th days)