NCT07569302Not yet recruitingPhase 2
Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger . A Randomized Controlled Study
Bedaya Hospital1 site in 1 country196 target enrollmentStarted: June 1, 2026Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Phase 2
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 196
- Locations
- 1
Study Overview
Brief Summary
The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol [a single bolos of HCG combined with two successive doses of a GnRH agonist ] with HCG [a single bolos administered 36 hours before oocyte retrieval ] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •GnRH antagonist IVF cycle
- •Normo-responders to induction of ovulation
Exclusion Criteria
- •Hypogonadotrophic hypogonadism
- •Endometriosis
- •History of recurrent abortion
Arms & Interventions
Modified dual trigger group
Experimental
HCG is administered 36 hours before ovum pickup and two successive doses of GnRH are administered 36 and 24 hours before ovum pickup.
Intervention: Modified dual trigger (Drug)
HCG group
Active Comparator
A single dose of HCG is administered 36 hours before oocyte retrieval
Intervention: HCG (Drug)
Investigators
Study Sites (1)
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