Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics

• Conditions: Diabetes Mellitus

• Registration Number: NCT00698698
• Lead Sponsor: Dow University of Health Sciences

Brief Summary

Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication. Tear proteins are easy to collect causing no harm to a patient and different studies indicate that tear proteins of diabetic patients are significantly different from non diabetic population. This difference in the composition of tear proteins become more pronounced with advancement of diabetic retinopathy.

Detailed Description

Diabetes mellitus causes a significant alteration in tear proteins. If we analyze tear proteins by means of electrophoresis, HPLC, and mass spectroscopy.

We can find different type of tear proteins in different grades of diabetic retinopathy these biomarkers can help in mass screening , diagnosis and management of diabetic population.

Study Timeline

• Study First Submitted: 2008-06-13
• Study First Submitted QC: 2008-06-16
• Study First Posted: 2008-06-17
• Status Verified: 2009-01
• Study Start: 2009-01
• Last Update Submitted: 2009-01-30
• Last Update Posted: 2009-02-02
• Primary Completion: 2010-12
• Study Completion: 2011-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 350

Inclusion Criteria

• diabetic patients with type 2 diabetes
• age above 30
• willing to participate

Exclusion Criteria

• ocular surface disorders.
• collagen vascular diseases
• Limbal hyperemia
• previous ocular surgery
• creatinine level above 1.0
• liver diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Dow University of Health Sciences; 🇵🇰 Karachi, Sindh, Pakistan