Voluntary motor activity in Restless Legs Syndrome and Periodic Limb Movements in Sleep

Completed

• Conditions: Periodic Limb Movements in Sleep; Restless Legs Syndrome; 10040998

• Registration Number: NL-OMON36343
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Right-handed
Age > 18 years
RLS Patients with PLM:
- fullfilling the criteria for RLS
- Periodic Limb Movement Index (= PLMI) > 25
PLMS patients:
- not fullfilling the criteria for RLS
- PLMI > 25
Normal controls
- not fullfilling the criteria for RLS
- PLMI < 5
RLS patients without PLM:
- fullfilling the criteria for RLS
- PLMI < 5

Exclusion Criteria

- other neuropsychiatric diseases
- causes of secondary PLMS such as Obstructive Sleep Apneu Syndrome, reumatoid artritis, anaemia
- centrally active drugs, apart form RLS or PLMS medication
- contra-indications for Transcranial Magnetic Stimulation (pregnancy, elektronic devices such as pacemaker)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Voluntary fine motor activity will be studied using a manipulandum: a<br /><br>joystick-like device that permits movements in the wrist. Performance (speed,<br /><br>position relative to the manipulandum and position relative to the task) will<br /><br>be compared between groups and controls.<br /><br>Transcranial magnetic stimulation (TMS) will be used to study sensorimotor<br /><br>integration and intracortical inhibition. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>