Efficacy of 12 weeks and sustainability of oral nutrition supplementation enriched with HMB and UC-II® combined with exercise training on osteoarthritis-related symptoms and inflammatory biomarkers among older adults with knee osteoarthritis: a randomized controlled trial

Powerlife (M) Sdn. Bhd.0 个研究点目标入组 80 人开始时间: 2024年4月17日最近更新: 2024年7月8日

适应症

试验速览

暂无简介。

•1. Malaysians aged >=50 years old with at least mild osteoarthritis as diagnosed by a physician or clinical radiologist and do not suffer from diseases as mentioned in the exclusion criteria (see participant exclusion criteria)
•2. Able to communicate in Malay or English language
•3. Able to eat and drink safely without modified texture diets

•1. Receiving enteral tube feeding (ETF), parenteral nutrition or consuming ONS (or those who had consumed ONS in the past 4 weeks prior to the study)
•2. Institutionalised older adults, bedridden or having severe health problems
•3. Suffering from chronic kidney disease, dementia, liver failure, malignancy, gastrointestinal diseases, thyroid disorders, palliative care for terminal disease, stroke
•4. Suffering from other type of arthritis; rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, post-meniscectomy OA, femoro-patellar OA, Genuvarum/valgum
•5. Suffering from major psychiatric illness
•6. Consuming medications that could affect muscle mass and/or function (e.g., HMG-CoA reductase inhibitors, steroids) within 1 year before enrolling in the study
•7. Physical disabilities (unable to walk even with a walking aid)
•8. Currently participating in other clinical trials
•9. Participants with claustrophobia (for participants selected to undergo MRI)
•10. Participants with metallic implants, such as prostheses, shrapnel or aneurysm clips, or electric implants, such as cardiac pacemakers (for participants selected to undergo MRI)

发起方

Powerlife (M) Sdn. Bhd.