The effect of exercise on the prevention of endothelial ischemia-reperfusion injury

Completed

• Conditions: coronary artery disease; 10011082

• Registration Number: NL-OMON40007
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-11-28
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 17

Inclusion Criteria

- Healthy volunteers >18 years
- Written informed consent

Exclusion Criteria

-Presence of an absolute contra-indication for the performance of exercise (see also SOP Inspanningstest Department of Physiology):

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in endothelial function (measured with flow mediated dilation) after<br /><br>ischaemia reperfusion injury (induced by 20 minutes ischemia) with and without<br /><br>precedence of an acute bout of moderate-intensity endurance or (isocaloric)<br /><br>high-intensity interval exercise. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nitrite/nitrate in plasma</p><br>