Immune response of fractional doses of Inactivated Poliovirus Vaccine (IPV) administered intradermally in the Sultanate of Oma

Completed

• Conditions: Poliomyelitis vaccination; Infections and Infestations; Poliomyelitis

• Registration Number: ISRCTN17418767
• Lead Sponsor: World Health Organization (WHO) (Switzerland)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-08-15
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. Healthy Omani newborns (greater than 2.5 kg, apgar score greater than 9 at five minutes)
2. Living within the catchment area of the participating study site
3. Newborns delivered by caesarean section

Exclusion Criteria

1. Newborns requiring hospitalisation (except if in hospital because of maternal admission)
2. Birth weight below 2.5 kg
3. Apgar score less than 9 at five minutes
4. Non-Omani
5. Residence outside the catchment area, or families expecting to move away during the study period
6. A diagnosis or suspicion of immunodeficiency disorder (either in the participant or in a member of the immediate family) will also render the newborn ineligible for the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Seroconversion after three doses of IPV (fractional or full doses).

Secondary Outcome Measures

Name	Time	Method
Seroconversion after each dose of vaccine.