A 12-Week,Double-Blind, Placebo-Controlled Trial of LY2428757 in Patients With Type 2 Diabetes Mellitus

Eli Lilly0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Have type 2 diabetes mellitus for at least 6 months prior to entering the trial.
•-Treated with diet and exercise alone or in combination with at least 1000 mg/day of metformin for at least 2 months prior to screening.
•-Have an HbA1c value of 7.0% - 10.0% at screening
•-Women of child-bearing potential must test negative for pregnancy at screening and agree to abstain from heterosexual intercourse for the duration of the study, or use 2 effective forms of birth control during the study.
•-Have a body mass index (BMI) between 25 and 40 kg/m2 at screening
•-Stable weight during the 3 months prior to screening.

•-Use any antidiabetic agent other than metformin during the 2 months prior to screening.
•-Have a gastrointestinal disease that significantly impacts gastric emptying or motility or have undergone bariatric surgery.
•-Are currently taking prescription or over-the counter medications to promote weight loss.
•-Have been previously diagnosed with pancreatitis
•-Women who are breastfeeding.
•-Have a history of myocardial infarction, unstable angina, coronary artery bypass graft (CABG), percutaneous coronary intervention, transient ischemic attack, stroke or decompensated congestive heart failure in the past 6 months.
•-Have poorly controlled hypertension

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