CPAP Versus High Flow Nasal Cannula Oxygen for the Treatment of Patients With Community Acquired Pneumonia Induced Acute Hypoxemic Respiratory Failure in the Ward
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- days free from ventilatory support
研究概览
简要总结
the study compares two non-invasive respiratory support modalities ie CPAP and High Flow nasal cannula oxygen for the treatment of severe hypoxemic respiratory failure attributed to Community acquired Pneumonia.
详细描述
CPAP and High Flow nasal cannula oxygen are two established modalities for non-invasive respiratory support . In COVID pandemic era both CPAP and HFNO were widely used in the ward for the treatment of COVID-19 induced acute hypoxemic respiratory failure in order to prevent progression to intubation. Head to head comparison between the two modalities mentioned for the treatment of severe hypoxemic respiratory failure is not available neither in COVID pneumonia or Community acquired pneumonia (CAP).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with age >18 year old.
- •Been hospitalized with community acquired pneumonia
- •hospitalized in common ward (not ICU)
- •Patients should have pneumonia- pulmonary infiltrates in chest-xray and hypoxemic respiratory failure.
- •Patients should be unable to keep: SpO2>93% with FiO2 50%, or SpO2 95% with FiO2 50% and have evidence of respiratory distress defined as Respiratory rate -RR>35/min
排除标准
- •Need for immediate or imminent intubation
- •not fit for escalation of treatment: defined as intubation, mechanical ventilation and ICU support.
- •Pregnant women
- •Contraindication to CPAP or HFNO
结局指标
主要结局
days free from ventilatory support
时间窗: 28 days
days without support with either mechanical ventilation, HFNO, CPAP
次要结局
- treatment failure defined(28 days)
- days under non-invasive respiratory support(28 days)
- hospital length of stay(28 days)
- intubation rate(28 days)
- hospital mortality(28 days)
- Partial pressure of oxygen PaO2 change at 2h, 12h and 24h(28 days)
研究者
IOANNA SIGALA
Pulmonologist-Intensivist
Evangelismos Hospital