A prospective, randomised, controlled evaluation of the effects of optimisation of cerebral oxygenation and depth of anaesthesia on postoperative cognitive functioning in older patients undergoing major orthopaedic and abdominal surgery
Completed
- Conditions
- Post-operative cognitive decline (POCD)Surgery
- Registration Number
- ISRCTN39503939
- Lead Sponsor
- King's College London (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 250
Inclusion Criteria
1. Aged 65 years or over
2. Due to undergo major abdominal or orthopaedic surgery or a healthy relative of such a patient
3. Able to give informed consent
4. Fluency in English
Exclusion Criteria
1. Mild cognitive impairment
2. Dementia
3. Physical disability which would interfere with cognitive interviewing (blindness, inability to write)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. The Cambridge Assessment for Mental Disorders in the Elderly (section B)
- Secondary Outcome Measures
Name Time Method 1. The Bristol Activities of Daily Living Scale<br>2. The Cornell depression scale<br>3. The Quality of Life instrument (EQ-5D, EuroQolGroup)<br>4. Cognitive Drug Research Battery (choice reaction time, simple reaction time, digit vigilance reaction time, number vigilance, visual working memory)<br>5. Client Service Receipt Inventory<br>6. Confusion Assessment Method<br>7. Trail-making A and B<br>8. Stroop Test