Cardiac arrhythmias in Dravet syndrome<br>

Completed

• Conditions: Dravet syndrome; epilepsy; 10007521; 10039911

• Registration Number: NL-OMON41805
• Lead Sponsor: Stichting Epilepsie Instellingen Nederland

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-09-01
• Results First Posted: 2019-07-18
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

1) Dravet syndrome with a known pathogenic SCN1A mutation
2) seizure frequency * 1/week (all seizure types expect for absences or myoclonias)
3) no self-harm
4) age * 6 years

Exclusion Criteria

None

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Ictal asystole (sinus arrest * 3 s) or ictal bradycardia (< 2nd heart rate<br /><br>percentile for age)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Ictal QT lengthening or shortening</p><br>