CTRI/2021/06/034033Not yet recruitingPhase 3
Submandibular gland sparing plus parotid sparing versus parotid sparing alone using volumetric modulated arc therapy (VMAT) in head and neck squamous cell carcinomas - a single blind phase 3 randomized controlled trial
Trial Snapshot
- Phase
- Phase 3
- Status
- Not yet recruiting
- Sponsor
- JIPMER
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
Inclusion Criteria
- •1. Patients over 18 years of age
- •2. Patients with ECOG performance status 0 - 2
- •3. Patients of squamous cell carcinoma of the
- •head and neck planned for radical radiation with or without concurrent chemotherapy treated with volumetric modulated arc radiotherapy
Exclusion Criteria
- •1. Patients with previous history of radiotherapy to head and neck
- •2. Patients with T1N0M0 carcinoma glottis
- •3. Patients with carcinoma of the head and
- •neck in whom the submandibular glands are enclosed completely in the clinical target volume.
- •4. Tumour involvement of both the submandibular glands
- •5. Preâ??existing salivary gland disease
- •6. Previous or concurrent illness that would
- •compromise completion of treatment or
- •7. Patient receiving prophylactic amifostine or pilocarpine
Investigators
Similar Trials
Not yet recruiting
Phase 3
Evaluation of salivary gland function before and after salivary gland sparing radiotherapy in head-neck cancers.CTRI/2022/06/043364Jawaharlal institute of Postgraduate Medical Education and Research
Completed
Phase 1
Anatomical Relationship of Level IB Lymph Nodes to the Submandibular Gland in Cancer PatientsCarcinomaNCT00728130Southern Illinois University22
Completed
Phase 2
evel IB dissection with Intact Submandibular gland versus En bloc Level IB dissection for Oral cavity cancersCTRI/2022/05/042344AIIMS Rishikesh46
Completed
Phase 3
Xerostomia after submandibular gland sparing radiotherapyoropharyngeal cancer10027656NL-OMON31993niversitair Medisch Centrum Utrecht50
Completed
Not Applicable
Comparison between Submandibular salivary gland removal vs preservation during surgery for early stages of oral squamous cell carcinomaCTRI/2021/01/030755Kalinga Institute Of Medical Sciences20