Effects of a six-week mechanism based psychotherapy program on biobehavioral mechanisms of reactive aggressive behavior in patients with a borderline personality disorder.
- Conditions
- 301.83 Borderline personality disorderF60.31
- Registration Number
- DRKS00009445
- Lead Sponsor
- Klinik für Allgemeine Psychiatrie
- Brief Summary
Although no significant difference in M-OAS overt aggression between treatments was found at post-treatment (adjusted difference in mean 3.49 (95% CI = [-5.32;12.31], p=0.22), the MAAP group showed a clinically relevant decrease of aggressive behavior of 65% on average (vs. 33% in the NSSP group), with a particularly strong improvement among those with the highest baseline aggression. Most notably, significant differences in reduction of overt aggression between MAAP and NSSP were found at follow-up. Conclusions: Patients with BPD and aggressive behavior benefitted from a short 6-week group psychotherapy with improvement particularly visible at 6-months follow-up. Future studies have to show whether effects are specific of MAAP.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 64
current borderline personality disorder - aggressive behavior - place of residence in a 70 km radius around the University medical center
- pregnancy - current psychotherapy - change in psychotropic medication three weeks prior to study admission - current/ past epilepsy - known brain traumata, brain tumor or other significant neurological/ medical factors - current/past bipolar I disorder or schizophrenia - substance addiction during the last two years prior to study admission - current substance abuse - left handedness
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Interaction effect (time of measurement x intervention): patients in the MAAP-intervention show a significant higher reduction of their aggressive behavior over two weeks post-treatment, examined with the OAS-M, compared to patients in the NSSP-intervention, who receive the same amount of therapy.
- Secondary Outcome Measures
Name Time Method • OAS-M at T2, 6 months after therapy<br>• Psychometric outcome: anger, assessed with the Ecological Momentary Assessment” (EMA); Mean of three daily surveys (State subscale of the state-Trait Anger Inventory) over two weeks (T0 (pre), T1 (post) and T2)<br>