NCT00821522已完成1 期
The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery
Robert Kramer, MD2 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2008年11月最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl.
研究概览
简要总结
Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient undergoing heart surgery on cardiopulmonary bypass.
排除标准
- •Known peripheral vascular disease of the lower extremities associated with active skin necrosis or infection.
- •End-stage renal disease.
- •Inability to give informed consent.
结局指标
主要结局
Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl.
时间窗: 48 hours after surgery.
次要结局
- Oliguria.(12 hours after surgery.)
- Incidence of acute kidney injury as defined by post-operative elevation in NGAL.(3 hours after cardiopulmonary bypass.)
研究者
Robert Kramer, MD
Thoracic Surgery, MD
MaineHealth
研究点 (2)
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