The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery

Robert Kramer, MD1 site in 1 country120 target enrollmentNovember 2008

ConditionsAcute Kidney Insufficiency Acute Renal Insufficiency Acute Kidney Injury Ischemic Preconditioning

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Acute Kidney Insufficiency
Sponsor: Robert Kramer, MD
Enrollment: 120
Locations: 1
Primary Endpoint: Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl.
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.

Registry

clinicaltrials.gov

Start Date

November 2008

End Date

May 2010

Last Updated

4 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Robert Kramer, MD

Responsible Party

Sponsor Investigator

Principal Investigator

Robert Kramer, MD

Thoracic Surgery, MD

MaineHealth

Eligibility Criteria

Inclusion Criteria

•Patient undergoing heart surgery on cardiopulmonary bypass.

Exclusion Criteria

•Known peripheral vascular disease of the lower extremities associated with active skin necrosis or infection.
•End-stage renal disease.
•Inability to give informed consent.

Outcomes

Primary Outcomes

Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl.

Time Frame: 48 hours after surgery.

Secondary Outcomes

Oliguria.(12 hours after surgery.)
Incidence of acute kidney injury as defined by post-operative elevation in NGAL.(3 hours after cardiopulmonary bypass.)