NCT00821522已完成1 期
The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery
Robert Kramer, MD1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2008年11月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl.
研究概览
简要总结
Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient undergoing heart surgery on cardiopulmonary bypass.
排除标准
- •Known peripheral vascular disease of the lower extremities associated with active skin necrosis or infection.
- •End-stage renal disease.
- •Inability to give informed consent.
研究组 & 干预措施
Preconditioning
Active Comparator
干预措施: Remote Ischemic Preconditioning (Procedure)
Control
No Intervention
Standard clinical management during cardiac surgery.
结局指标
主要结局
Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl.
时间窗: 48 hours after surgery.
次要结局
- Oliguria.(12 hours after surgery.)
- Incidence of acute kidney injury as defined by post-operative elevation in NGAL.(3 hours after cardiopulmonary bypass.)
研究者
Robert Kramer, MD
Thoracic Surgery, MD
MaineHealth
研究点 (1)
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