The effect of very low carbohydrate and high fat diet on gastric cancer
- Conditions
- Gastric cancer.Malignant neoplasm of stomach
- Registration Number
- IRCT2016102830538N1
- Lead Sponsor
- Vice chancellor of research, International Campus, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
( diagnosis of gastric adenocarcinoma; patients with ECOG performance status of 0 to 4; patients who have not been gastrectomized; blood, liver, and kidney should be functional; patients aged 18 years and older; both genders will be recruited; leucocytes count be over 3000 cell in each mm3 of blood; neutrophil count be over 1500 cubic millimeter of blood; platelets be over 1500 per each cubic millimeter of blood; total bilirubin lower than 3mg/dL; serum creatinine lower than 2mg/dL; serum potassium less than 5 mmol/L). (Exclusion criteria: Patients which live alone during the intervention without others attendance; Diabetes; patients receiving Insulin or other anabolic drugs along with intervention; pyruvate dehydrogenase complex deficiency; and inherited porphyria ; MCT oil consumption until 5 weeks before recruitment in study; Having congestive heart failure; Uncontrolled hypertension. Severe steatorrhea and diarrhea; Gastrointestinal obstruction; Patients which could not resist the intervention for any reason; Frequent incidence of hypoglycemia during first week of intervention).
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Carcinoembryonic antigen (CEA). Timepoint: Before and after intervention. Method of measurement: ELISA.;Ca19-9. Timepoint: Before and after intervention. Method of measurement: ELISA.;Serum ketone bodies. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;FBS. Timepoint: Before and after intervention. Method of measurement: Spectrophotometer.;Body Mass Index (BMI). Timepoint: Before and after intervention. Method of measurement: Formula.;Hs-CRP. Timepoint: Before and after intervention. Method of measurement: Auto analyzer.
- Secondary Outcome Measures
Name Time Method Insulin. Timepoint: Before and after intervention. Method of measurement: Auto analyzer.;Resting energy expenditure (REE). Timepoint: Before and after intervention. Method of measurement: Gathering the produced CO2 by indirect calorimetry.;HOMA-IR. Timepoint: Before and after intervention. Method of measurement: Is calculated by the formula.;Serum Lactate. Timepoint: Before and after intervention. Method of measurement: Auto analyzer.;CBC-diff. Timepoint: Before and after intervention. Method of measurement: Complete blood count and differential.;Serum Albumin. Timepoint: Before and after intervention. Method of measurement: Auto analyzer.;Karnofsky score. Timepoint: Before and after intervention. Method of measurement: Observation.;Eastern Cooperative Oncology Group (ECOG). Timepoint: Before and after intervention. Method of measurement: Observation.;Bioelectric Impedance Analysis (BIA). Timepoint: Before and after intervention. Method of measurement: Weight.