Multicenter Phase II sequential study of S-1/Oxaliplatin (SOX) and Bevacizumab as first line therapy followed by S-1/Irinotecan (IRIS) and Cetuximab as second line in patients with metastatic colorectal cancer. : A SOBIC study - SOBIC study

The median second progression-free survival was 24.2 months (95% confidence interval [CI] 17.7 35.2). The response rate after first- and second-line chemotherapy was 46.7% and 20%, respectively. The median overall survival was 35.2 months (95% CI: 27.8 to not reached). The main grade 3,4 adverse events were sensory neuropathy (18%), fatigue (10%), and anorexia (8%). There were no treatment-related deaths among patients administered the first-line and second-line regimens.