Cognitive Flexibility Training in Persistent Pain

Not Applicable

Completed

• Conditions: Chronic Pain
• Interventions: Behavioral: Training

• Registration Number: NCT03398408
• Lead Sponsor: Washington University School of Medicine

Brief Summary

To determine whether participation in a cognitive training program over a training period of five weeks improves cognitive flexibility in patients with chronic hip, knee, and back pain.

Detailed Description

This project is a single-center prospective, randomized study to assess whether cognitive flexibility can be improved through training on a Lumosity®-based training module over the course a five week timeframe in patients with chronic hip, knee, and back pain; and whether changes in cognitive flexibility will correlate with perceived pain scores.

Study Timeline

• Study First Submitted: 2017-12-28
• Study Start: 2017-12-29
• Study First Submitted QC: 2018-01-05
• Study First Posted: 2018-01-12
• Primary Completion: 2019-08-07
• Study Completion: 2019-08-07
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-05
• Last Update Posted: 2020-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Adults age 18 to 70 with chronic hip, knee, or low back pain for >3 months
• Documented moderate to severe chronic pain
• English as a primary language
• Access to a computer at home and an email account

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Exclusion Criteria

• Diagnosed Alzheimer's or documented severe cognitive impairment
• Lack of email/lack of basic computer skills
• Has undergone an interventional pain procedure within one week prior to enrollment
• Are scheduled to undergo a pain procedure during the five weeks of complete cognitive training

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention	Training	Patients in both groups will complete paper-pencil TMT A and B and the CWMST, the computer-based TMT A and B and Color Match, and NCPT tests upon enrollment into the study. Participants in the intervention group will then be provided with the Lumosity cognitive flexibility training module and complete daily training for a total of five weeks. 1-3 days after completion of their training, all patients will be invited to complete the computerized versions of the TMT A and B, Color Match, and NCPT tests again on their personal computers.

Primary Outcome Measures

Name	Time	Method
Does cognitive training over five weeks improve cognitive flexibility performance scores in chronic hip, knee, and back pain patients?	Up to 5 months	The primary outcome, i.e. NCPT score, will be assessed before and after five weeks of cognitive training. T-test will be used to compare the change in NCPT score between the training and the control group.

Trial Locations

Locations (1)

Washington University in St. Louis; 🇺🇸 Saint Louis, Missouri, United States