Efficacy of Transcranial Magnetic Stimualtion in relieving symtooms in Parkinsons Disease.
- Conditions
- Health Condition 1: null- Parkinsons DiseaseHealth Condition 2: G20- Parkinsons disease
- Registration Number
- CTRI/2018/01/011563
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Diagnosis of clinically definite PD, defined by UKPD brain bank clinical and diagnostic criteria. With presence of at least 1 out of 3 cardinal motor features of PD (resting tremor, rigidity, and postural impairment like bradykinesia);
2.PD patients of both gender with H&Y stage from 1 to 2.
3.PD patients between age 45 to 75 on stable medication for at least 30 days
1.Features suggestive of other causes of Parkinsonism/ Parkinson-plus syndromes;
2.History of surgery on brain for any indication, significant headaches, epilepsy or seizure disorder, mass lesions, or major head trauma leading to loss of consciousness of any length;
3.Family (1st degree relatives) history of epilepsy;
4.History of schizophrenia, schizoaffective disorder, other psychosis, claustrophobia; rapid-cycling bipolar illness, alcohol/drug abuse within the past year;
5.Need for rapid clinical response due to conditions such as psychosis, or suicide tendency;
6.Patients with uncontrolled hypertension and diabetes and other uncontrolled medical illness. Patients with hypertension or diabetes would be included only if they are stable on medication for last six months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method i.To compare the status of cortical plasticity between two treatment groups (M1, SMA) using FDG-PET. <br/ ><br>Timepoint: Baseline 0 day <br/ ><br>Post Sham at 4th week <br/ ><br>Post Real at 8th week <br/ ><br>[Baseline:-After recruitment <br/ ><br>Post-Sham:-After 4 sessions of Sham TMS <br/ ><br>Post-Real:- After 4 sessions of Real TMS.]
- Secondary Outcome Measures
Name Time Method To compare the clinical condition of the patients in the two treatment groups on the basis of UPDRS. <br/ ><br>Timepoint: Baseline 0 day <br/ ><br>Post Sham at 4th week <br/ ><br>Post Real at 8th week <br/ ><br>[Baseline:-After recruitment <br/ ><br>Post-Sham:-After 4 sessions of Sham TMS <br/ ><br>Post-Real:- After 4 sessions of Real TMS.]