CTRI/2025/04/084820尚未招募不适用
Epigenetic Vulnerability to Alcohol Dependence: A Comparative Analysis of DNA Methylation and Gene Expression of Candidate Genes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- Hypo or hypermethylation of the candidate gene assessed using methylation specific PCR and their impact on gene expression
研究概览
简要总结
This is a Cross-Sectional Observational Case-Control Study aims to analyze and compare DNA methylation changes in the key genes associated with alcohol dependence between individuals with alcohol dependence and healthy controls and to identify dysregulated pathways associated with chronic alcohol consumption, thereby suggesting the development of potential biomarkers for treating and preventing alcohol dependence. Recruitment will begin from March 20 2025 after getting the CTRI reference number.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •Individual diagnosed with alcohol dependence by a qualified psychiatrist at the Department of Psychiatry, Kasturba Medical College, MAHE Manipal Capable of providing informed consent Willing to participate in blood sampling For Healthy.
- •Individual with no history of alcohol dependence and other substance use. Not having any first-degree relatives with a history of a major psychiatric disorder No psychiatric disorder screened using the Self Reporting Questionnaire SRQ Age and sex-matched to the alcohol-dependent group Capable of providing informed consent Willing to participate in blood sampling.
排除标准
- •Individuals currently diagnosed with major chronic or terminal diseases such as cardiovascular diseases and cancers major infectious conditions and severe mental disorders as well as lactating mothers and pregnant women Because these conditions can potentially influence DNA methylation patterns Individual having substance dependence other than alcohol and tobacco For Healthy.
- •Individuals having first-degree relatives with a history of a major psychiatric disorder Individuals currently diagnosed with major chronic or terminal diseases such as cardiovascular diseases and cancers major infectious conditions and severe mental disorders as well as lactating mothers and pregnant women.
结局指标
主要结局
Hypo or hypermethylation of the candidate gene assessed using methylation specific PCR and their impact on gene expression
时间窗: Baseline
次要结局
- Identification of dysregulated pathways & comorbidities associated with alcohol dependence(Baseline)
研究者
Mohd Jahid Riyaz Ahmad Khan
Kasturba Medical College Manipal Academy of Higher Education Manipal
研究点 (2)
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