the effect of systemic GCSF administration in infertile women with repeated IVF failure
- Conditions
- Female Infertility.inability to achieve a pregnancy
- Registration Number
- IRCT201503119568N11
- Lead Sponsor
- Research Deputy, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria:
1. age < 40 years
2. having = 2 failed IVF attempts where at least 3 good embryos were transferred
3. the lack of contraindications for GCSF treatment (sickle cell disease, chronic neutropenia, known past or present malignancy, renal insufficiency, upper respiratory infection, pneumonia, and congenital fructose intolerance)
4. not having any systemic disease
1. having inadequate thin endometrium (< 7mm) on the day of hCG injection
2. the detection of Asherman’s syndrome, fibroids, and polyps in diagnostic hysteroscopy
3. having any medical illness upon enrollment (including hypertension, diabetes, antiphospholipid syndrome, systemic lupus erythematosus, thrombophilia, thyroid disorders)
4. refusing to give an informed consent to participate in the study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Chemical pregnancy. Timepoint: 2 weeks after IVF and embryo transfer. Method of measurement: serum ß-HCG level.
- Secondary Outcome Measures
Name Time Method Implantation. Timepoint: 4 weeks after IVF and embryo transfer. Method of measurement: transvaginal sonography to detect gestational sacs.;Clinical Pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: detection of gestational sac and fetal heart rate on transvaginal sonography.