Evaluation of Micro-osteoperforations to Accelerate Orthodontic Tooth Movement

Not Applicable

Completed

• Conditions: Orthodontic Tooth Movement
• Interventions: Procedure: Micro-osteoperforations

• Registration Number: NCT05281588
• Lead Sponsor: Pontifícia Universidade Católica de Minas Gerais

Brief Summary

This clinical trial evaluated the efficacy of micro osteoperforations in accelerating the retraction of maxillary incisors.

Detailed Description

This single-centered randomized clinical trial evaluated the effects of micro-osteoperforations in the retraction of maxillary incisors in patients who required the extraction of the first premolars to correct malocclusion. The canine retraction was performed in a previous step. The possible effects of micro-osteoperforantions in the following parameters were evaluated in the upper arch: anteroposterior incisors and first molars displacement, space closure, inclination and length of central incisors.

Study Timeline

• Study Start: 2016-02
• Primary Completion: 2019-10
• Study Completion: 2020-03
• Status Verified: 2022-03
• Study First Submitted: 2022-03-07
• Study First Submitted QC: 2022-03-07
• Study First Posted: 2022-03-16
• Last Update Submitted: 2022-03-16
• Last Update Posted: 2022-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• both male and female subjects
• 16 or more years old
• orthodontic need of upper incisors extractions
• presence of all upper permanent teeth with exception of the third molars.

Exclusion Criteria

• diseases and medications that were likely to affect bone biology
• pregnancy
• poor oral hygiene
• previous orthodontic treatment
• evidence of bone loss
• active periodontal disease
• smoking
• syndromes or cleft patients
• severe crowding or Class II malocclusion (Pg-Nper > 18 mm, ANB > 7º, SN-GoGn > 38º e overjet > 10 mm).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Micro-osteoperforations	Micro-osteoperforations	Micro-osteoperforations- assisted upper incisors retraction

Primary Outcome Measures

Name	Time	Method
Space closure	Up to 4 months	The space closure was assessed by the distance between the most menial point of the medial surface of the canine to the most distal point of the distal surface of the lateral incisor.
Anteroposterior displacement of the upper incisors	Up to 4 months	The anteroposterior displacement of the upper incisors was assessed on superimposed digital models through the distance of points on the incisal edge and palatal cervical margin of these teeth to a coronal reference plan created on the initial CBCT scan.

Secondary Outcome Measures

Name	Time	Method
Changes of the inclination of the central incisors	Up to 4 months	The initial and final CBCT were superimposed by the "voxel-based method" in the Dolphin Imaging software (Chatsworth, CA, USA), using the cranial base as reference. The inclination of the central incisors was then assessed by means of the angle formed by the long axis of each central incisor in the initial and final CBCT.
Changes of the length of the central incisors	Up to 4 months	The initial and final length of the central incisors were measured by creating a 2D line, passing through the lowest point of the incisal edge and the highest point of the root apex. To perform these measurements, a sagittal cut was used in which the longest length of these teeth was seen.
First molars anchorage loss	Up to 4 months	The first molars anchorage loss was assessed on superimposed digital models through the distance of a point on the mesiobuccal cuspid to a coronal reference plan created on the initial CBCT scan.

Trial Locations

Locations (1)

Pontifícia Universidade Católica de Minas Gerais; 🇧🇷 Belo Horizonte, Minas Gerais, Brazil