Pharmacokinetic comparison of oral and local administration of flurbiprofen: A Clinical study in patients with ligament injuries
- Conditions
- anterior cruciate ligament injury
- Registration Number
- JPRN-UMIN000017405
- Lead Sponsor
- Hokkaido University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 16
Not provided
(1) patients who had received any flurbiprofen or ketoprofen preparation within 2 weeks before the start of the study, (2) patients who had received an injection of a steroid, sodium hyaluronate, etc, into the affected joint within 1 week before the start of the study, (3) patients with wounds or diseases in the skin around the knee, (4) patients with a history of hypersensitivity to a certain drug, (5) patients suffering from a peptic ulcer, (6) patients with severe underlying internal diseases (heart disease, renal disease, coronary artery disease, hematological disease, etc.) or history of such diseases, (7) patients with a history of hypersensitivity to a certain NSAID, (8) patients with a history of asthma due to hypersensitivity to aspirin, (9) pregnant or possibly pregnant women or nursing women and (10) other patients judged, for any reason, to be unsuitable for the study by the attending physician.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tissue concentrations of flurbiprofen after topical application and oral administration of flurbiprofen
- Secondary Outcome Measures
Name Time Method aboratory evaluation of blood and urine samples before and after flurbiprofen administration