NCT02087202Unknown不适用
Hyperalgesia and NMDA Receptor Antagonist
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 主要终点
- pain
研究概览
简要总结
NMDA receptor is administered and postoperative remote hyperalgesia is investigated.
详细描述
NMDA receptor is adminstered and postoperative tertiary hyperalgesia is investigated.
QST and pain measures for remote hyperalgesia are compared between control and magnesium or ketamine group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •contraindication to the study drugs
研究组 & 干预措施
magnesium
Experimental
magnesium is added perioperatively to those patients undergoing staged total knee arthroplasty and other surgeries.
干预措施: Magnesium Sulfate (Drug)
ketamine
Experimental
ketamine is administered to those patients undergoing stated TKA and other operations.
干预措施: ketamine (Drug)
结局指标
主要结局
pain
时间窗: until 1 month from the end of the operation
pain (QST and pain measures )until 1 month from the end of the operation
次要结局
未报告次要终点
研究者
Kim Mihyun
clinical professor
Seoul St. Mary's Hospital
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