Safe Use of CPAP and PEEP During Induction of General Anesthesia

Not Applicable

Completed

• Conditions: General Anesthesia
• Interventions: Procedure: Pressure controlled ventilation with PEEP; Procedure: Manual ventilation without PEEP

• Registration Number: NCT04271683
• Lead Sponsor: Region Västmanland

Brief Summary

The study compares the safety of using pressure controlled ventilation with a positive end-expiratory pressure (PEEP) during induction of general anaesthesia immediately after apnoea to a standard method starting ventilation manually without PEEP immediately after apnoea.

Detailed Description

Using a continuous positive pressure (CPAP) during preoxygenation, followed by pressure controlled ventilation with PEEP after apnoea during induction of general anesthesia, might offer several benefits but safety issues needs more investigation. This study compares the safety of using pressure controlled with PEEP during induction of general anesthesia immediately after apnoea to a standard method starting ventilation manually without PEEP immediately after apnoea.

Study Timeline

• Study First Submitted: 2020-02-13
• Study First Submitted QC: 2020-02-13
• Study First Posted: 2020-02-17
• Study Start: 2021-10-19
• Primary Completion: 2021-12-20
• Study Completion: 2021-12-21
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-04
• Last Update Posted: 2023-05-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Normal or overweight patients scheduled for day case surgery in general anesthesia.
• American Society of Anesthesiologists functional class I-III.
• Body Mass Index 18.5-30.

Exclusion Criteria

• Increased risk of regurgitation of gastric content.
• Symptomatic asthma, COPD or heart failure.
• Peripheral oxygen saturation (SpO2) breathing air <94 %
• Anticipated difficult airway.
• Beard.
• Anatomical features making it difficult to keep a tight seal during maskventilation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pressure controlled ventilation with PEEP	Pressure controlled ventilation with PEEP	In this group, ventilation after apnoea during induction of general anesthesia starts with pressure controlled ventilation with PEEP.
Manual ventilation without PEEP	Manual ventilation without PEEP	In this group, ventilation after apnoea during induction of general anesthesia starts with manual ventilation without PEEP.

Primary Outcome Measures

Name	Time	Method
Number of breaths until return of CO2.	2 minutes	When starting ventilation after apnea the number of breaths given until the return of CO2 is at least 1.3 kPa at a respiratory frequency of 10 per minute.

Trial Locations

Locations (1)

Lennart Edmark; 🇸🇪 Västerås, Sweden