Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.

Not Applicable

Completed

• Conditions: Respiratory Insufficiency
• Interventions: Other: Pathophysiology of gas exchange

• Registration Number: NCT05392062
• Lead Sponsor: CHU de Reims

Brief Summary

The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS). In this case, very few studies have investigated changes in gas exchange during COVID-19 progression in spontaneously breathing patients. The investigators purpose in this study to explore the pathophysiology of gas exchange and time course changes in spontaneously breathing patients with acute respiratory failure due to COVID-19. Moreover, our aim is to identify early markers associated with worsening respiratory failure and requiring endotracheal intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-09
• Study First Submitted: 2021-08-09
• Study First Submitted QC: 2022-05-25
• Study First Posted: 2022-05-26
• Primary Completion: 2023-01-15
• Study Completion: 2023-04-15
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-11
• Last Update Posted: 2024-12-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Respiratory insufficiency	Pathophysiology of gas exchange	Subject with respiratory insufficiency

Primary Outcome Measures

Name	Time	Method
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and need to intubation.	Lenght of hospital stay in intensive care unit	From date of admission in intensive care unit (ICU) until the date of death or disharge from ICU, assessed up to 90 days

Secondary Outcome Measures

Name	Time	Method
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D90.	Day 90	No provided
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D28.	Day 28	No provided
Association between intrapulmonary right-to-left shunt, ventilatory ratio with percentage of lung damage on chest CT-scan.	At admission	No provided

Trial Locations

Locations (1)

Damien JOLLY; 🇫🇷 Reims, France