Acute Decrease in Serum Testosterone After Glucose and Protein Beverages in Adolescent Males
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Testosterone Change
研究概览
简要总结
The purpose of this study was to determine the effect of acute protein and glucose intake on testosterone levels measured in adolescent boys and determine whether changes in testosterone levels are associated with alterations in short-term food intake. It was hypothesized that 1) ingestion of a protein beverage would result in no change of testosterone levels whereas glucose would result in a significant decrease of testosterone levels 60 minutes after ingestion and 2) decreases of testosterone levels as a result of the glucose preload would predict food intake for boys of similar body size. The first objective was to investigate the effect of an acute protein or glucose drink on testosterone levels and the second objective was to determine whether changes of testosterone levels associate with food intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
The experimental beverages contained either 1g of glucose monohydrate (BioShop Canada Inc., Burlington, Ontario, Canada) or 1g of protein (plain whey-protein isolate; BiPro USA., Eden Prairie, Minnesota, U.S.A) per kg of bodyweight. A non-calorie drink was used as control. All beverages were flavoured with 1.5ml of chocolate extract (Vanilla Food Company, Markham, Ontario, Canada) to account for the flavor differences and mixed with 500ml of water. The whey protein and control beverages were sweetened with 0.2g sucralose (Tate & Lyle, Stoney Creek, Ontario, Canada) in order to match sweetness with the glucose beverage.
入排标准
- 年龄范围
- 9 Years 至 18 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •9-18 years, healthy, male.
排除标准
- •History of prematurity, chronic illness, were taking any medications known to affect glucose homeostasis, appetite or pubertal development.
研究组 & 干预措施
Control
干预措施: Control (Dietary Supplement)
Protein
干预措施: Protein (Dietary Supplement)
Glucose
干预措施: Glucose (Dietary Supplement)
结局指标
主要结局
Testosterone Change
时间窗: 0-65 minutes
The first blood draw was taken prior to ingesting the experimental beverage at baseline (0 minutes). Participants were then given 5 minutes to ingest the beverage, and blood was later obtained 20, 35 and 65 minutes after baseline blood draw. Units were measured in ng/dl.
次要结局
- Appetite Biomarkers- Insulin(0-85 minutes)
- Appetite Biomarkers- Active Ghrelin(0-85 minutes)
- Subjective Appetite- Determination to eat(0-85 minutes)
- Subjective Appetite- Prospective Food Consumption(0-85 minutes)
- Food Intake(65-85 minutes)
- Appetite Biomarkers- Glucose(0-85 minutes)
- Appetite Biomarkers- Glucagon-like peptide-1(0-85 minutes)
- Subjective Appetite- Hunger(0-85 minutes)
- Subjective Appetite- Fullness(0-85 minutes)
研究者
G. Harvey Anderson
Full Professor
University of Toronto