The Relationship Between Serum Cystatin C and PET-DAT Study in Patients With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 121
- 试验地点
- 1
- 主要终点
- Cystatin C assesses the loss of dopaminergic neurons
研究概览
简要总结
To investigate the relationship between serum cystatin C and dopamine receptor(DAT) loss in patients with parkinson's disease(PD)
详细描述
Number of people suffered from Parkinson disease (PD) is increasing every year. PET imaging of dopamine transport receptors（DAT） serves as the gold standard for the diagnosis and monitoring of PD development. However, due to high costs and radiation reasons, it is not suitable for long-term follow-up. Serum cystatin C can be easily obtained and cheap as an indicator. In recent years, studies have gradually found that it is related to the progression of H&Y staging of Parkinson's disease. To this extent, we want to further explore whether it can reflect the loss of DAT in the brain. Explore whether it can partially replace the role of DAT imaging for future clinical evaluation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged between 20 and 80 years and whose laboratory results included the levels of serum Cystatin C within a month from the PET-DAT were recruited.
排除标准
- •To make the study cohort more homogeneous, PD patients with either a long-standing duration (≥5 years) or advanced Hoehn and Yahr (H&Y) staging (≥3) were excluded.
结局指标
主要结局
Cystatin C assesses the loss of dopaminergic neurons
时间窗: through study completion, an average of 1 year
Explore whether Cystatin C can respond to the loss of dopaminergic neurons
次要结局
未报告次要终点