Development of a Musculoskeletal Model of the PIP Joint

Not Applicable

Completed

• Conditions: Patient Specific Computational Modeling
• Interventions: Other: Motion capture; Diagnostic Test: MR scan; Diagnostic Test: CT scan

• Registration Number: NCT03094962
• Lead Sponsor: University of Southampton

Brief Summary

The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data.

Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model.

Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-21
• Study First Submitted: 2017-03-09
• Study First Submitted QC: 2017-03-22
• Study First Posted: 2017-03-29
• Primary Completion: 2017-09-05
• Study Completion: 2017-09-05
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-14
• Last Update Posted: 2018-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• In general good health
• University of Southampton members of staff
• Over 18 years old and able to provide informed consent
• No known problems relating to the PIP joint

Exclusion Criteria

• Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved.
• Those undergoing treatment related to the PIP joint
• No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Motion capture, MR scan, CT scan	CT scan	All volunteers will go through the same data collection process
Motion capture, MR scan, CT scan	MR scan	All volunteers will go through the same data collection process
Motion capture, MR scan, CT scan	Motion capture	All volunteers will go through the same data collection process

Primary Outcome Measures

Name	Time	Method
Capturing hand kinematics using Vicon optical motion capture	3 years	Capture hand kinematics of 10 healthy volunteers
Capturing images of the soft tissue in the hand using MR imaging	3 years	Capture MR images of the hand for same 10 healthy volunteers as Outcome 1
Capturing images of the bony structures in the hand using CT scanning	3 years	Capture CT images of the hand for same 10 healthy volunteers as Outcome 1

Trial Locations

Locations (1)

University Hospital Southampton; 🇬🇧 Southampton, Hampshire, United Kingdom