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Clinical Trials/NCT01271829
NCT01271829CompletedNot Applicable

Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans

Loma Linda University2 sites in 1 country30 target enrollmentStarted: January 2011Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
30
Locations
2
Primary Endpoint
Satiety

Study Overview

Brief Summary

The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.

Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Masking
Single (Investigator)

Eligibility Criteria

Ages
23 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • 23-60 years old
  • BMI 23-32
  • Stable weight for 6 months
  • Live or work near Loma Linda University

Exclusion Criteria

  • Heavy involvement in sports
  • Dependent on caffeine

Outcomes

Primary Outcomes

Satiety

Time Frame: 12 hours

The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode

Secondary Outcomes

  • post-ingestion glycemic index(3 hours)
  • insulin response(3 hours)
  • appetite-related gastrointestinal peptide and hormone release(3 hours)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Joan Sabate,DrPH, MD

Chair, Department of Nutrition

Loma Linda University

Study Sites (2)

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