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临床试验/NCT01271829
NCT01271829已完成不适用

Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans

Loma Linda University1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2011年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
30
试验地点
1
主要终点
Satiety

研究概览

简要总结

The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.

Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
盲法
Single (Investigator)

入排标准

年龄范围
23 Years 至 60 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •23-60 years old
  • •BMI 23-32
  • •Stable weight for 6 months
  • •Live or work near Loma Linda University

排除标准

  • •Heavy involvement in sports
  • •Dependent on caffeine

研究组 & 干预措施

Control

No Intervention

While on the control arm subjects will be given a meal with no avocado.

Avocado supplement

Active Comparator

While on the avocado supplement arm subjects will be given a meal in which a given amount of calories will be replaced by calories contributed by avocados.

干预措施: Avocado supplement (Dietary Supplement)

Avocado included

Active Comparator

While on the avocado included arm subjects will be given a meal in which the calories of avocado will be added to the calories of the control meal.

干预措施: Avocado included (Dietary Supplement)

结局指标

主要结局

Satiety

时间窗: 12 hours

The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode

次要结局

  • post-ingestion glycemic index(3 hours)
  • insulin response(3 hours)
  • appetite-related gastrointestinal peptide and hormone release(3 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Joan Sabate,DrPH, MD

Chair, Department of Nutrition

Loma Linda University

研究点 (1)

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