Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Satiety
研究概览
简要总结
The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.
Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 23 Years 至 60 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •23-60 years old
- •BMI 23-32
- •Stable weight for 6 months
- •Live or work near Loma Linda University
排除标准
- •Heavy involvement in sports
- •Dependent on caffeine
研究组 & 干预措施
Control
While on the control arm subjects will be given a meal with no avocado.
Avocado supplement
While on the avocado supplement arm subjects will be given a meal in which a given amount of calories will be replaced by calories contributed by avocados.
干预措施: Avocado supplement (Dietary Supplement)
Avocado included
While on the avocado included arm subjects will be given a meal in which the calories of avocado will be added to the calories of the control meal.
干预措施: Avocado included (Dietary Supplement)
结局指标
主要结局
Satiety
时间窗: 12 hours
The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode
次要结局
- post-ingestion glycemic index(3 hours)
- insulin response(3 hours)
- appetite-related gastrointestinal peptide and hormone release(3 hours)
研究者
Joan Sabate,DrPH, MD
Chair, Department of Nutrition
Loma Linda University
