The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney
Not Applicable
Completed
- Conditions
- Losartan Adverse ReactionUropathyUropathy Obstructive
- Interventions
- Drug: Cozaar (Losartan Potassium 25mg)Drug: Placebo
- Registration Number
- NCT04278495
- Lead Sponsor
- Mansoura University
- Brief Summary
Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
Inclusion Criteria
- anuric and oliguric patients
- calculuar ureteral obstruction
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Exclusion Criteria
- anomalous kidney
- bilateral obstructed kidney
- history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors
- ASA score of >3
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Losartan Cozaar (Losartan Potassium 25mg) to receive the medication Cozaar (Losartan Potassium 25mg "Merck Sharp \& Dohme-UK"), Placebo Placebo to receive either placebo
- Primary Outcome Measures
Name Time Method Renographic glomerular filtration rate of the affected kidney. 3 months assessed by radioisotope renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) in ml/min
- Secondary Outcome Measures
Name Time Method Serum creatinine change 3 months assessed by serum creatnine in mg/dl
Trial Locations
- Locations (1)
Urology and nephrology center
🇪🇬Mansoura, Outside U.S./Canada, Egypt