NCT04278495已完成不适用
The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney: A Double Blind Randomized Placebo-controlled Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Renographic glomerular filtration rate of the affected kidney.
研究概览
简要总结
Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •anuric and oliguric patients
- •calculuar ureteral obstruction
排除标准
- •anomalous kidney
- •bilateral obstructed kidney
- •history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors
- •ASA score of >3
研究组 & 干预措施
Losartan
Active Comparator
to receive the medication Cozaar (Losartan Potassium 25mg "Merck Sharp & Dohme-UK"),
干预措施: Cozaar (Losartan Potassium 25mg) (Drug)
Placebo
Placebo Comparator
to receive either placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Renographic glomerular filtration rate of the affected kidney.
时间窗: 3 months
assessed by radioisotope renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) in ml/min
次要结局
- Serum creatinine change(3 months)
研究者
研究点 (1)
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