Comparison of Skin Carotenoid Levels Between Subjects With History of Cutaneous Squamous Cell Carcinoma and Subjects With History of Basal Cell Carcinoma Versus a Control Group
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 81
- 试验地点
- 1
- 主要终点
- Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Control Subjects
研究概览
简要总结
The purpose of this study is to determine the difference of skin carotenoid levels between subjects with previous squamous cell carcinomas (SCC), subjects with previous basal cell carcinomas (BCC) and a control group.
详细描述
There has been experimental and clinical research evaluating association of different carotenoids and incidence of malignancies, including Non- Melanoma Skin Cancer (NMSC). An easy and inexpensive way to determine which subjects would benefit from supplementation with carotenoids or retinoids could be the measurement of skin carotenoid levels.The least invasive way to perform it is through Raman spectroscopy which is a technique that uses a laser light that can be used to quantify carotenoids on the skin. We will compare the skin carotenoid levels of subjects with previous history of SCC or BCC and subjects without history of previous NMSC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects between 50 and 75 years old without history of previous SCC or BCC.
- •Fitzpatrick skin types I-IV.
- •Willing and able to understand and sign informed consent.
- •Able to complete study and comply with study procedures
排除标准
- •Regular ingestion of supplements containing carotenoids or vitamin A in the past 4 weeks.
- •Use of topical retinoids in the past 4 weeks.
- •Treatment with systemic retinoids in the past 6 months.
- •Dermatologic conditions that require the use of interfering topical or systemic therapy or that might interfere with study assessments such as, but not limited to, palmar psoriasis, hand dermatitis or palmo-plantar keratoderma.
- •Previous history of psoriasis.
- •Clinically significant abnormal findings or conditions, which might, in the opinion of the Principal Investigator, interfere with study evaluations or pose a risk to subject safety during the study.
- •Subjects who are known to be pregnant or planning a pregnancy.
结局指标
主要结局
Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Control Subjects
时间窗: baseline
Mean carotenoid levels in subjects with a history of squamous cell carcinoma were compared to mean carotenoid levels in control subjects without a history of nonmelanoma skin cancer.
次要结局
- Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Subjects With History of Basal Cell Carcinoma(baseline)
- Skin Carotenoid Levels in Subjects With History of Basal Cell Carcinoma Versus Control Group(baseline)
研究者
Alexandra Kimball
Director, Clinical Unit for Research Trials in Skin
Massachusetts General Hospital