Hybrid Training and Middle Age
- Conditions
- Middle AgedNon-alcoholic Fatty Liver DiseaseWomen's HealthHybrid TrainingMetabolic Syndrome
- Registration Number
- NCT05231564
- Lead Sponsor
- University of Sistan and Baluchestan
- Brief Summary
Modern living and physical inactivity results in many ailments, including obesity, non-alcoholic fatty liver disease (NAFLD), and inflammatory issues.
Though there are a lot of studies on physical training, there is little detail on hybrid training or electrical and voluntary contractions of the musculature. This study investigated the efficiency of hybrid training in biochemistry, ultrasound, and proinflammatory outcomes in middle-aged sedentary and obese women with NAFLD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 15
- Sedentary women with one to two exercise sessions or less per month
- BMI equal to or above 30 kg/m-2
- WHR equal or above 0.85 m
- Confirmed NAFLD, with grade 2 and 3
- Systolic blood pressure not less than 130 mm Hg and diastolic blood pressure not less than 85 mm Hg
- Increased AST and ALT
- Mean age 45-65 years
- Use of 140 grams or more of ethanol per week
- History of depression in the last 6 months
- History of chronic or acute viral hepatitis
- Drug-related liver disease and chronic liver disease
- History of diabetes
- Uncontrolled hypertension
- Myocardial infarction
- Chronic kidney disease
- Hyperthyroidism or heart failure
- Those who have weight loss programs or medical contraindications for physical training
- Serious arterial hemorrhagic disorders
- Serious neurological diseases
- Advanced atherosclerosis
- Elevated fever
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Alanine transaminases Pre-study in u/l
Aspartate transaminases Pre-study in u/l
Proinflammatory cytokine (interleukin -6) Pre-study in pg/ml
Ultrasonic assessment Pre-study Grade of liver steatosis
WHR Pre-study Waist-to-hip ratio in cm
SBP/DBP Pre-study Systolic blood pressure/Diastolic blood pressure
HDL Cholesterol Plasma Pre-study in mg/dl
Body Weight Pre-study in kg
Body Mass Index Pre-study in kg/m-2
Fasting blood sugar Pre-study in mg/dl
- Secondary Outcome Measures
Name Time Method Body Weight six-week in kg
Aspartate transaminases six-week in u/l
Alanine transaminases six-week in u/l
Fasting blood sugar six-week in mg/dl
Proinflammatory cytokine (interleukin -6) six-week in pg/ml
Ultrasonic assessment six-week Grade of liver steatosis
WHR six-week Waist-to-hip ratio in cm
SBP/DBP six-week Systolic blood pressure/Diastolic blood pressure
HDL Cholesterol Plasma six-week in mg/dl
Body Mass Index six-week in kg/m-2
Related Research Topics
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Trial Locations
- Locations (1)
Mohammadreza Rezaeipour (MD, PhD)
🇮🇷Zahedan, Sistan And Baluchestan, Iran, Islamic Republic of
Mohammadreza Rezaeipour (MD, PhD)🇮🇷Zahedan, Sistan And Baluchestan, Iran, Islamic Republic of