Hybrid Training and Middle Age

Not Applicable

Completed

• Conditions: Middle Aged; Non-alcoholic Fatty Liver Disease; Women's Health; Hybrid Training; Metabolic Syndrome

• Registration Number: NCT05231564
• Lead Sponsor: University of Sistan and Baluchestan

Brief Summary

Modern living and physical inactivity results in many ailments, including obesity, non-alcoholic fatty liver disease (NAFLD), and inflammatory issues.

Though there are a lot of studies on physical training, there is little detail on hybrid training or electrical and voluntary contractions of the musculature. This study investigated the efficiency of hybrid training in biochemistry, ultrasound, and proinflammatory outcomes in middle-aged sedentary and obese women with NAFLD.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-11-01
• Primary Completion: 2019-12-02
• Study Completion: 2020-02-01
• Study First Submitted: 2022-01-19
• Study First Submitted QC: 2022-01-29
• Status Verified: 2022-02
• Study First Posted: 2022-02-09
• Last Update Submitted: 2022-02-09
• Last Update Posted: 2022-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 15

Inclusion Criteria

• Sedentary women with one to two exercise sessions or less per month
• BMI equal to or above 30 kg/m-2
• WHR equal or above 0.85 m
• Confirmed NAFLD, with grade 2 and 3
• Systolic blood pressure not less than 130 mm Hg and diastolic blood pressure not less than 85 mm Hg
• Increased AST and ALT
• Mean age 45-65 years

Exclusion Criteria

• Use of 140 grams or more of ethanol per week
• History of depression in the last 6 months
• History of chronic or acute viral hepatitis
• Drug-related liver disease and chronic liver disease
• History of diabetes
• Uncontrolled hypertension
• Myocardial infarction
• Chronic kidney disease
• Hyperthyroidism or heart failure
• Those who have weight loss programs or medical contraindications for physical training
• Serious arterial hemorrhagic disorders
• Serious neurological diseases
• Advanced atherosclerosis
• Elevated fever

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Alanine transaminases	Pre-study	in u/l
Aspartate transaminases	Pre-study	in u/l
Proinflammatory cytokine (interleukin -6)	Pre-study	in pg/ml
Ultrasonic assessment	Pre-study	Grade of liver steatosis
WHR	Pre-study	Waist-to-hip ratio in cm
SBP/DBP	Pre-study	Systolic blood pressure/Diastolic blood pressure
HDL Cholesterol Plasma	Pre-study	in mg/dl
Body Weight	Pre-study	in kg
Body Mass Index	Pre-study	in kg/m-2
Fasting blood sugar	Pre-study	in mg/dl

Secondary Outcome Measures

Name	Time	Method
Body Weight	six-week	in kg
Aspartate transaminases	six-week	in u/l
Alanine transaminases	six-week	in u/l
Fasting blood sugar	six-week	in mg/dl
Proinflammatory cytokine (interleukin -6)	six-week	in pg/ml
Ultrasonic assessment	six-week	Grade of liver steatosis
WHR	six-week	Waist-to-hip ratio in cm
SBP/DBP	six-week	Systolic blood pressure/Diastolic blood pressure
HDL Cholesterol Plasma	six-week	in mg/dl
Body Mass Index	six-week	in kg/m-2

Trial Locations

Locations (1)

Mohammadreza Rezaeipour (MD, PhD); 🇮🇷 Zahedan, Sistan And Baluchestan, Iran, Islamic Republic of