Calcium Metabolism in Asian Adolescents

Not Applicable

Completed

• Conditions: Adolescent Development; Bone Mineralization
• Interventions: Dietary Supplement: Beverage containing calcium citrate malate; Dietary Supplement: Beverage fortified with calcium citrate malate

• Registration Number: NCT00591708
• Lead Sponsor: Purdue University

Brief Summary

Maximizing calcium retention by the skeleton within the genetic potential is a key strategy to prevent osteoporosis. It has been shown that calcium retention varies between blacks and whites and between gender within race. This study is designed to study the relationship between calcium intakes and calcium retention in Asian adolescent girls and boys. It is hypothesized that calcium intakes which maximize calcium retention will be lower in Asians than for whites studies under the same conditions. In addition it is thought that the differences between races in the physiological mechanisms involved in calcium metabolism will result in a lower calcium intake required to observe a plateau in calcium retention. This is turn could be translated into lower calcium requirements in Asians relative to Caucasians for achieving optimal peak bone mass.

Detailed Description

Adolescent Asian boys and girls will consume a controlled diet for two three-week periods. The basal diet will contain 600 mg/d calcium and will be supplemented with beverages fortified with calcium citrate malate to achieve a range of intakes from 600-2100 mg Ca/d. Each participant will be studied on one of four combinations of a lower and a higher calcium intake within that range in a cross-over design.

Study Timeline

• Study Start: 2004-07
• Primary Completion: 2005-08
• Study Completion: 2005-08
• Study First Submitted: 2007-12-26
• Study First Submitted QC: 2008-01-10
• Study First Posted: 2008-01-11
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-03
• Last Update Posted: 2018-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• healthy teens of Asian descent

Exclusion Criteria

• malabsorptive disorders
• anemia
• smoking, illegal drugs
• oral contraceptives
• pregnancy
• drugs that influence calcium metabolism
• body weight for height greater than 85 percentile

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
A	Beverage containing calcium citrate malate	Supplementation of a lower level of calcium (0-400 mg/d) via calcium fortified beverages (calcium citrate malate) to a basal diet of 600 mg/d for 21 consecutive days. All excreta will be collected.
B	Beverage fortified with calcium citrate malate	Supplementation of a higher level of calcium (500-1300 mg/d) via calcium fortified beverages (calcium citrate malate) to a basal diet of 600 mg/d for 21 consecutive days. All excreta will be collected.

Primary Outcome Measures

Name	Time	Method
Calcium retention (mg/d)	Metabolic balance will be determined over a two week period on a controlled diet after equilibration for one week on the same diet.

Secondary Outcome Measures

Name	Time	Method
Serial serum biochemistry profiles (PTH, 1,25 dihydroxy-vitamin D, calcium)	Six serial measurements in 10 hours after ingestion of a calcium load representing one third of the daily consumption

Trial Locations

Locations (1)

Department of Foods and Nutrition, Purdue University; 🇺🇸 West Lafayette, Indiana, United States