Calcium Metabolism in Asian Adolescents
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Calcium retention (mg/d)
研究概览
简要总结
Maximizing calcium retention by the skeleton within the genetic potential is a key strategy to prevent osteoporosis. It has been shown that calcium retention varies between blacks and whites and between gender within race. This study is designed to study the relationship between calcium intakes and calcium retention in Asian adolescent girls and boys. It is hypothesized that calcium intakes which maximize calcium retention will be lower in Asians than for whites studies under the same conditions. In addition it is thought that the differences between races in the physiological mechanisms involved in calcium metabolism will result in a lower calcium intake required to observe a plateau in calcium retention. This is turn could be translated into lower calcium requirements in Asians relative to Caucasians for achieving optimal peak bone mass.
详细描述
Adolescent Asian boys and girls will consume a controlled diet for two three-week periods. The basal diet will contain 600 mg/d calcium and will be supplemented with beverages fortified with calcium citrate malate to achieve a range of intakes from 600-2100 mg Ca/d. Each participant will be studied on one of four combinations of a lower and a higher calcium intake within that range in a cross-over design.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 11 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •healthy teens of Asian descent
排除标准
- •malabsorptive disorders
- •smoking, illegal drugs
- •oral contraceptives
- •pregnancy
- •drugs that influence calcium metabolism
- •body weight for height greater than 85 percentile
研究组 & 干预措施
B
Supplementation of a higher level of calcium (500-1300 mg/d) via calcium fortified beverages (calcium citrate malate) to a basal diet of 600 mg/d for 21 consecutive days. All excreta will be collected.
干预措施: Beverage fortified with calcium citrate malate (Dietary Supplement)
A
Supplementation of a lower level of calcium (0-400 mg/d) via calcium fortified beverages (calcium citrate malate) to a basal diet of 600 mg/d for 21 consecutive days. All excreta will be collected.
干预措施: Beverage containing calcium citrate malate (Dietary Supplement)
结局指标
主要结局
Calcium retention (mg/d)
时间窗: Metabolic balance will be determined over a two week period on a controlled diet after equilibration for one week on the same diet.
次要结局
- Serial serum biochemistry profiles (PTH, 1,25 dihydroxy-vitamin D, calcium)(Six serial measurements in 10 hours after ingestion of a calcium load representing one third of the daily consumption)
研究者
Berdine Martin
Research Scientist, Nutrition Science
Purdue University