Comparison of Surgical Stress in Patients Undergoing TURP Versus HOLEP Surgery by Measuring Perioperative Systemic Inflammatory Markers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prostate Hyperplasia
- Sponsor
- Adana City Training and Research Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- inflamatory markers
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.
Detailed Description
Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.
Investigators
Baris Arslan, MD
Baris Arslan, MD, Principal investigator
Adana City Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •ASA scores I-III patients
- •having benign prostatic hyperplasia
- •undergoing HOLEP or TURP surgery under general anesthesia
Exclusion Criteria
- •immune system disease,
- •diabetes mellitus,
- •malignancy other than prostate disease,
- •history of steroid use,
Outcomes
Primary Outcomes
inflamatory markers
Time Frame: Change from baseline CD4+/CD8+ at postoperative 0th and postoperative 24th hourL-6 (pg/ml) and TNF-alfa (pg/ml)
CD4+/CD8+
Stress hormone levels
Time Frame: Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour
Adrenaline (ng/L)
stress hormone levels
Time Frame: Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour
Cortisol (microg/dl)