Inflammatory Markers: HOLEP Versus TURP
- Conditions
- Prostate Hyperplasia
- Registration Number
- NCT05108662
- Lead Sponsor
- Adana City Training and Research Hospital
- Brief Summary
Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.
- Detailed Description
Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 50
- ASA scores I-III patients
- having benign prostatic hyperplasia
- undergoing HOLEP or TURP surgery under general anesthesia
- immune system disease,
- diabetes mellitus,
- malignancy other than prostate disease,
- history of steroid use,
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method inflamatory markers Change from baseline CD4+/CD8+ at postoperative 0th and postoperative 24th hourL-6 (pg/ml) and TNF-alfa (pg/ml) CD4+/CD8+
Stress hormone levels Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour Adrenaline (ng/L)
stress hormone levels Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour Cortisol (microg/dl)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Adana City Training and Research Hospital
🇹🇷Adana, Turkey
Adana City Training and Research Hospital🇹🇷Adana, Turkey