Comparison of Surgical Stress in Patients Undergoing TURP Versus HOLEP Surgery by Measuring Perioperative Systemic Inflammatory Markers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- inflamatory markers
研究概览
简要总结
Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.
详细描述
Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •ASA scores I-III patients
- •having benign prostatic hyperplasia
- •undergoing HOLEP or TURP surgery under general anesthesia
排除标准
- •immune system disease,
- •diabetes mellitus,
- •malignancy other than prostate disease,
- •history of steroid use,
结局指标
主要结局
inflamatory markers
时间窗: Change from baseline CD4+/CD8+ at postoperative 0th and postoperative 24th hourL-6 (pg/ml) and TNF-alfa (pg/ml)
CD4+/CD8+
Stress hormone levels
时间窗: Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour
Adrenaline (ng/L)
stress hormone levels
时间窗: Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour
Cortisol (microg/dl)
次要结局
未报告次要终点
研究者
Baris Arslan, MD
Baris Arslan, MD, Principal investigator
Adana City Training and Research Hospital