The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline

Not Applicable

• Conditions: Wound Heal
• Interventions: Drug: Hyaluronic acid; Dietary Supplement: honey

• Registration Number: NCT05161403
• Lead Sponsor: Cairo University

Brief Summary

This study aims to evaluate the effect of hyaluronic acid and honey compared to saline in healing of multiple extraction sockets of primary teeth in a group of children aging from Two to Seven years old.

Detailed Description

A dental extraction is one of the most unpleasant experiences in children, especially for those who have undergone traumatic experiences, and this is likely to reduce future visits to the dental clinic if the treatment is not managed properly.

Alveolar osteitis is one of the most common complications following dental extraction. It is considered one of the most studied complications in dentistry, and many risk factors contribute to its occurrence including being a female, young age, tobacco use, difficult or traumatic extractions, pre-existing infection, and use of vasoconstrictor in local anesthesia. Alveolar osteitis occurs during the first three days following the day of extraction, so that the socket is devoid of the blood clot, resulting in the exposure of the bare alveolar bone.

Many medicines were and are still used in treating wounds, but they are somewhat expensive.

Study Timeline

• Study First Submitted: 2021-10-26
• Status Verified: 2021-11
• Study First Submitted QC: 2021-12-03
• Last Update Submitted: 2021-12-03
• Study First Posted: 2021-12-17
• Last Update Posted: 2021-12-17
• Study Start: 2022-02-22
• Primary Completion: 2023-09-04
• Study Completion: 2023-09-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• • Age: from Two to Seven years old age.

  • Both genders.
  • Children with badly decayed multiple primary teeth beyond repair.
  • Treated under general anesthesia.

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Exclusion Criteria

• • History of systemic disease.

  • Allergy to honey.
  • Repeatedly used honey during the previous 6 month period.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hyaluronic acid.	honey	1mm layer of hyaluronic acid on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.
Honey	honey	1mm layer of Honey on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.
Saline	honey	a piece of gauze moistened with normal saline will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.
Hyaluronic acid.	Hyaluronic acid	1mm layer of hyaluronic acid on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.
Honey	Hyaluronic acid	1mm layer of Honey on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.
Saline	Hyaluronic acid	a piece of gauze moistened with normal saline will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.

Primary Outcome Measures

Name	Time	Method
Wound healing size in length and width	After one week will be calculated the size (lentgh and width) of socket	There is only one outcome (wound healing); • Multiple measurements (Digital caliper, color, palpation, presence of pus, gingival margin status).; 1. Digital caliper: a device used to calculate the size of the socket (width and length) buccolingual in mesiodistal with measurement of mm.; 2. Color: normal (pinkish gingiva) Up normal (reddish gingiva); 3. Palpation: if there is bleeding or not.; 4. Presence of pus: yes or no; 5. Gingival margin: epithelization (yes or no)