The Effect of Gaucher Disease on Bone Cells - The Effect of Gaucher Disease on Bone Cells

Vrije Universiteit Medisch Centrum0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•1. Men and women between the age of 18 and 65 years
•2. Informed consent
•3. Patient with a proven diagnosis of Gaucher disease
•4. Stable (< 5% change) body weight for at least 6 months and a BMI between 18-30;healthy controls
•1. Men and women between the age of 18 and 65 years
•2. Informed consent
•3. Stable (< 5% change) body weight for at least 6 months and a BMI between 18-30

•Patients and healthy controls:
•1. Documented inflammatory or malignant bowel disease
•2. Previous bowel surgery, both small intestine and/or colon, with the exception of appendicular surgery.
•3. Cholestatic disease defined by elevated values of AP or gammaGT > 2 x upper reference limit
•4. Fever of unknown cause during the past 4 weeks prior to study
•5. Co-morbidity influencing bone metabolism:
•Renal insufficiency (creatinin clearance < 40 ml/min)
•untreated hypo- / hyperthyroidism (stabily treated hypothyroidism may be included)
•Paget*s disease or other metabolic bone diseases, Cushing*s disease or hyperprolactinemia
•6. Patients who have received calcitonin, bisphosphonates and strontium within 1 year
•7. Use of corticosteroids current use and in the last 3 months in case of longterm use or in the last 6 weeks in case of induction therapy
•8. Patients who have been treated with anti-TNF in the last 6 months
•9. Use of antitrombotic agents
•10. Patients who are pregnant or breast-feeding

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