Can Injecting blood component (PRP) decrease the time taken to move the teeth during braces treatment

Phase 1

Completed

Brief Summary: prolonged treatment time has always been a area of concern in both patient and professional point of view. Inspite of the fact of losing interest and motivation to treatment , long treatment time has various adverse effects like enamel demineralization, dental caries, periodontitis which are the aftermath of compromised oral hygiene during a 20-30 months orthodontic treatment. It also increases the risk of orthodontically induced external root resorption due to prolonged inflammatory reaction. Thus reducing the overall treatment time not only increase the patient compliance but also reduces the adverse effects.Platelet rich plasma(PRP) an autologous platelet concentrate plays a important role in bone metabolism because of its ability to release of various cytokines and growth factors that modulate the metabolism.It is proposed that the Platelet Rich Plasma has a concentration dependent action having a pro-inflammatory action at high concentration. Localized growth factors are hypothesized to bring about acceleration in tooth movement by causing transient osteopenic effect mainly increasing the local inflammatory cytokines through chemotaxis and mesenchymal cell proliferation.Hence the study is aimed to verify the effects of locally injected Platelet Rich Plasma on the rate of tooth movement during maxillary canine retraction.

Recruitment & Eligibility

Inclusion Criteria

1. Healthy patients with good periodontal condition .
1. Patients within 15 â€“ 35 years irrespective of the gender..
1. Cases of Class II Div I or Bimaxillary protrusion requiring prior bilateral maxillary first premolar extraction.
1. Patient with no significant medical history or metabolic bone disease.
1. Patients with positive informed consent.

Exclusion Criteria

1. Patients who suffered recent major illness- reduced platelet count.
1. Patients with negative informed consent 3) Patients on regular antibiotics, steroids or anti inflammatory drugs.
1. Non compliant patient with poor oral hygiene.

Primary Outcome Measures

Name	Time	Method
Acceleration of Orthodontic tooth movement	0,7,21,30,60 days

Secondary Outcome Measures

Name	Time	Method
Increased Stability of the Tooth in its posiiton after the injection of PRP	0,7,21,30,60 days

Locations (1): Centre for Dental Education and Research
🇮🇳
Delhi, DELHI, India
Centre for Dental Education and Research
🇮🇳Delhi, DELHI, India
Saraa Angel L
Principal investigator
9654047794
saraaangal2011@gmail.com