The Effect of Negatively Fluid Balancing Speed for ICU Patients With Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- increased oxygenation index proportion at 24h
研究概览
简要总结
Previous studies have shown that a positive fluid balance was an independent factor of worse prognosis in ICU patients with acute respiratory distress syndrome (ARDS), and negative fluid balance has been demonstrated to increase oxygenation index, reduce time under mechanical ventilation and ICU length of stay with no noticeable adverse effects. But there is no evidence that faster speed of negative fluid balance would be more beneficial for ARDS patients. So researchers designed the study to prove the effect of negatively fluid balancing speed for ICU patients with ARDS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •·Patients with ARDS (Berlin 2012 criterion）
排除标准
- •Pregnant women
- •Unstable hemodynamics status
- •< 18 years old
结局指标
主要结局
increased oxygenation index proportion at 24h
时间窗: at the time of 24 hours
Oxygenation index equals arterial oxygen partial pressure/fraction of inspiration O2 (PO2/FIO2). Increased oxygenation index proportion at 24h equals (oxygenation index at 24h - oxygenation index at baseline)/ oxygenation index at baseline.
次要结局
- Duration of free mechanical ventilation(up to 28 days)
- Oxygenation index every day(up to 7 days)
- mortality(up to 28 days)
研究者
Bo Yao,phD
Clinician of intensive care unit, Principal Investigator
Qingdao University