Is Pancreaticobiliary Reflux in Patients With Cholelithiasis and Without Cholelithiasis a Normal Phenomenon?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 197
- 试验地点
- 1
- 主要终点
- Amylase and Lipase Values in Gallbladder Bile
研究概览
简要总结
Pancreaticobiliary reflux has been found in patients with cholelithiasis and gallbladder cancer associated with normal pancreaticobiliary union. However, the presence of pancreaticobiliary reflux has not been studied in patients without gallstones (healthy gallbladders).
The authors believe that pancreaticobiliary reflux might be a normal phenomenon in patients with and without gallstones, although in patients with cholelithiasis it might constitute a pathological condition associated with dismotility of the biliary tree and the sphincter of Oddi.
详细描述
The objective of this study is to measure the levels of amylase and lipase in gallbladder bile of patients without gallstones and compare these values to the values of amylase and lipase of patients with gallstones and normal pancreaticobiliary union evidenced by intraoperative cholangiography.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age older than 15 years of age
- •Elective surgery
- •Normal intraoperative cholangiography
- •Normal preoperative serum amylase and lipase values
排除标准
- •Common bile duct stones
- •Anatomic anomalies at the pancreaticobiliary junction evidenced by intraoperative cholangiography
- •Altered preoperative amylase and lipase levels
- •Altered preoperative hepatic function tests
- •Emergency surgery
结局指标
主要结局
Amylase and Lipase Values in Gallbladder Bile
时间窗: 24 hours
Normal values of lipase and amylase in gallbladder bile should be zero
次要结局
- Amylase and Lipase Values in Normal Gallbladders(24 hours)
- Amylase and Lipase Values in Gallbladders With Cholelithiasis(24 hours)
- Normal Operative Cholangiography(24 hours)
- Normal Preoperative Serum Values of Amylase and Lipase(24 hours)