Biomarkers of Increased Risk of Developing Metabolic Adaptation to Weight Loss
概览
- 阶段
- 不适用
- 干预措施
- lifestyle intervention with meal replacement program
- 疾病 / 适应症
- Weight Loss
- 发起方
- Medical College of Wisconsin
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- change in measured and predicted resting metabolic rate during and after weight loss
- 状态
- 进行中（未招募）
- 最后更新
- 2个月前
概览
简要总结
This study aims at identifying the neurohormonal biomarkers that characterize individuals at risk of greater metabolic adaptation to weight loss, a disproportionate decline in resting metabolic rate during and after weight loss.
研究者
Lisa Morselli, MD PhD
Assistant professor
Medical College of Wisconsin
入排标准
入选标准
- •BMI \> or = 30 any ethnicity
排除标准
- •weight \> or = 400 lbs.
- •diabetes (type 2 or type 1)
- •hypertension
- •heart disease
- •kidney disease
- •liver disease
- •active cancer
- •post solid organ or bone marrow transplant
- •breastfeeding
- •current smoker
研究组 & 干预措施
lifestyle intervention
Participants will be enrolled in a weight loss program based on lifestyle changes. They will be given a 6-month subscription to a calorie-reduced meal replacement program that also offers lifestyle coaching.
干预措施: lifestyle intervention with meal replacement program
结局指标
主要结局
change in measured and predicted resting metabolic rate during and after weight loss
时间窗: 18 months
resting metabolic rate will be measured by indirect calorimetry every 2 months for 6 months, then every 6 months for an additional 12 month. Predicted resting metabolic rate will be calculated with a mathematical formula at the same time points
次要结局
- change in circulating thyroid hormones during and after weight loss(18 months)
- change in circulating AgRP during and after weight loss(18 months)
- change in heart rate variability during and after weight loss(18 months)
- change in circulating leptin during and after weight loss(18 months)
- change in circulating GLP-1 during and after weight loss(18 months)
- change in 24h urine catecholamines during and after weight loss(18 months)
- change in circulating PYY during and after weight loss(18 months)