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Evaluation of Platelet Function in Pregnancy With Multiple Electrode Aggregometry

Conditions
Platelet Function
Pregnancy
Registration Number
NCT01881698
Lead Sponsor
Medical University of Vienna
Brief Summary

Establishment of a range of normal values in pregnancy with the Multiple Electrode Aggregometry (Multiplate@) device, a device that allows measurement of not only platelet count but platelet function. This has not been studied in ths special patient group. Results from this trial will be used as a basis for further investigation of abnormal platelet function in pregnancy.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
Female
Target Recruitment
200
Inclusion Criteria
  • pregnancy
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Exclusion Criteria
  • Rejection of informed consent
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Change of platelet function4x, as specified below

Measurement of change of platelet function by the Multiplate® device. First measurement (baseline measurement) at enrollment into the trial. Second measurement during government-mandated gynaecological evaluation, around the 20th week of pregnancy.

Third measurement immediately prior to delivery. Last measurement one week after delivery. 2nd, 3rd and 4th measurement for assessment of change from baseline.

Secondary Outcome Measures
NameTimeMethod
Platelet-associated complications4x, as specified below (baseline, 20th week)

Record of bleeding events, preeclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome.

Time points: at every assessment of primary outcome measure, as described above.

Trial Locations

Locations (1)

Universitätsklinik für Frauenheilkunde, Allgemeines Krankenhaus der Stadt Wien

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Vienna, Austria

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