Post-op oesophageal Doppler trial: effect on clinical outcome of extension of oesophageal Doppler goal-directed fluid optimisation into the post-operative recovery period
- Conditions
- Improving perioperative care for elective colorectal surgery within an Enhanced Recovery ProgrammeDigestive System
- Registration Number
- ISRCTN24020298
- Lead Sponsor
- Guy's & St Thomas' NHS Foundation Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 86
1. Consecutive elective or semi-elective patients due to undergo colorectal surgery as part of Enhanced Recovery Protocol involving resection or anastamosis of bowel
2. High-risk participants will be defined as having (1) pre-operative ASA grade III+ OR anaerobic threshold <11 ml/min/kg on cardiopulmonary exercise testing OR undergoing major complex surgery (as per OPCS 4.5 classification - Office of Population, Censuses and Surveys Classification of Surgical Operations and Procedures)
3. Ages 18 and over (no upper limit)
1. Emergency surgery
2. Lack of capacity to consent
3. Pregnancy
4. Contraindications to oesophageal Doppler probe:
4.1. Nasal injuries or polyps
4.2. Severe oesophageal/laryngeal/pharyngeal disease
4.3. Recent oesophageal/laryngeal/pharyngeal surgery
4.4. Thoracic aortic aneurysm
4.5. Severe bleeding diathesis
4.6. Long-term systemic steroid therapy
4.7. Portal hypertension
All excluded patients from patient groups to be reported in results
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post-operative length of stay (in days)
- Secondary Outcome Measures
Name Time Method 1. Oxygen delivery index at end of 16h post-operative recovery period<br>2. Mean oxygen delivery index over 16h post-operative recovery period<br>3. Morbidity<br>4. Functional recovery (mobility and return of gastrointestinal function)<br>5. In-hospital and 30-day mortality