Detectie van tumorweefsel met behulp van Bevacizumab-IRDye800CW in combinatie met een optisch beeldvormingssysteem bij patiënten die de HIPEC procedure ondergaan, een haalbaarheidsstudie.
Recruiting
- Conditions
- VEGF-Targeted Near-Infrared Fluorescence imaging in Peritoneal Carcinomatosis
- Registration Number
- NL-OMON27201
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Age ≥ 18 years.
-Patients with histopathological proven peritoneal carcinomatosis from colorectal origin who are
scheduled to undergo the HIPEC procedure
Exclusion Criteria
- Concomitant malignancies, except for adequately treated basocellular carcinoma of the skin or in situ carcinoma of the cervix uteri. Subjects with prior malignancies must be disease-free for at least 5 years.
- Distance metastasis (liver / lungs)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visualization of fluorescent tumor tissue confirmed by ex vivo immunohistochemistry or fluorescence microscopy of excised specimen.
- Secondary Outcome Measures
Name Time Method Improvement of the detection rate of tumor tissue using Multispectral Fluorescence Reflectance Imaging (MFRI) by calculation the Peritoneal Carcinomatosis Index (PCI).