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PROSTVAC®-VF/TRICOM™ Vaccine for the Treatment of Metastatic Prostate Cancer After Failing Hormone Therapy

Phase 2
Completed
Conditions
Prostate Cancer
Registration Number
NCT00078585
Lead Sponsor
Bavarian Nordic
Brief Summary

PROSTVAC-VF is an investigational cancer vaccine. The vaccine is based on the theory that the immune system can be taught to fight cancer by directing the immune system to attack specific targets found on cancer cells. These targets are called Tumor Associated Antigens, or TAA's. This trial will help determine if this vaccine can help fight cancer.

This multi-center, double-blind, randomized, empty vector-controlled trial is designed to evaluate the safety and efficacy of PROSTVAC-VF/TRICOM co-administered with GM-CSF versus the empty viral vector co-administered with placebo in the treatment of patients with androgen-independent prostate cancer (AIPC).

All patients will be required to sign an informed consent prior to the performance of any on-study procedures. Patients will be screened for eligibility within 14 days prior to vaccine administration. Patients who meet all inclusion and exclusion criteria will be centrally randomized into the study and will receive a unique patient identification number and a blinded treatment assignment. The ratio of active treatment to empty vector control (placebo) is 2:1.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
Male
Target Recruitment
120
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (47)

San Diego Urology Center

🇺🇸

La Mesa, California, United States

Urology Associates of Central California

🇺🇸

Fresno, California, United States

Western Clinical Research, Inc.

🇺🇸

Torrance, California, United States

Urology Centers of Alabama

🇺🇸

Homewood, Alabama, United States

Georgetown University Medical Center

🇺🇸

Washington, D.C., District of Columbia, United States

Washington Hospital Center

🇺🇸

Washington, D.C., District of Columbia, United States

North Idaho Urology

🇺🇸

Coeur d'Alene, Idaho, United States

Loma Linda University

🇺🇸

Loma Linda, California, United States

Alaska Clinical Research Center

🇺🇸

Anchorage, Alaska, United States

The Cancer Institute of New Jersey

🇺🇸

New Brunswick, New Jersey, United States

OSF Saint Francis Medical Center

🇺🇸

Peoria, Illinois, United States

Advanced Research Institute

🇺🇸

New Port Richey, Florida, United States

South Florida Medical Research

🇺🇸

Aventura, Florida, United States

Franklin Square Hospital Center

🇺🇸

Baltimore, Maryland, United States

Urology Group of New Mexico

🇺🇸

Albuquerque, New Mexico, United States

Pacific Clinical Research

🇺🇸

Santa Monica, California, United States

Arlington Cancer Center

🇺🇸

Arlington, Texas, United States

Prairie Medical Associates, Ltd.

🇺🇸

Chicago, Illinois, United States

Midtown Urology

🇺🇸

Atlanta, Georgia, United States

University of Pittsburgh

🇺🇸

Pittsburgh, Pennsylvania, United States

Atlantic Urology Medical Group

🇺🇸

Long Beach, California, United States

Connecticut Clinical Research Center

🇺🇸

Waterbury, Connecticut, United States

Urologic Associates, PC

🇺🇸

Davenport, Iowa, United States

Beth Israel Deaconess Medical Center

🇺🇸

Boston, Massachusetts, United States

The Urological Institute of Northeastern New York

🇺🇸

Albany, New York, United States

Columbia Presbyterian Medical Center

🇺🇸

New York, New York, United States

The Urology Center

🇺🇸

Greensboro, North Carolina, United States

Urology Clinic of North Texas, PA

🇺🇸

Dallas, Texas, United States

Texas Cancer Center

🇺🇸

Fort Worth, Texas, United States

Wyoming Research Foundation, Inc.

🇺🇸

Cheyenne, Wyoming, United States

Urology Associates Clinical Research

🇺🇸

Nashville, Tennessee, United States

UCHSC Anschutz Cancer Pavilion

🇺🇸

Aurora, Colorado, United States

University of Nebraska Medical Center

🇺🇸

Omaha, Nebraska, United States

Midwest Research Specialists, LLC

🇺🇸

Milwaukee, Wisconsin, United States

University of Vermont

🇺🇸

South Burlington, Vermont, United States

Lawrenceville Urology

🇺🇸

Lawrenceville, New Jersey, United States

AccuMed Research Associates

🇺🇸

Garden City, New York, United States

Medical and Surgical Specialists

🇺🇸

Galesburg, Illinois, United States

Metropolitan Urology

🇺🇸

Jeffersonville, Indiana, United States

Salt Lake Research

🇺🇸

Salt Lake City, Utah, United States

Medical College of Wisconsin

🇺🇸

Milwaukee, Wisconsin, United States

Texas Cancer Care

🇺🇸

Weatherford, Texas, United States

Carle Clinic Cancer Center

🇺🇸

Urbana, Illinois, United States

Nyack Hospital

🇺🇸

Nyack, New York, United States

Charleston Cancer Center

🇺🇸

Charleston, South Carolina, United States

Virginia Urology Center

🇺🇸

Richmond, Virginia, United States

McGuire Research Institute

🇺🇸

Richmond, Virginia, United States

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