Ultrasound Guided Serratus Anterior Versus Erector Spinae Block in Pain Alleviation in Acute Herpes Zoster

Not Applicable

Not yet recruiting

• Conditions: Acute Herpes Zoster Neuropathy
• Interventions: Procedure: ultrasound guided erector spine block; Procedure: Serratus anterior block

• Registration Number: NCT06476080
• Lead Sponsor: Minia University

Brief Summary

Acute herpes zoster pain is very severe . Conventional analgesics may be of no value. Regional blocks may play a role

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-06-15
• Study First Submitted QC: 2024-06-20
• Study First Posted: 2024-06-26
• Last Update Submitted: 2024-06-26
• Last Update Posted: 2024-06-27
• Study Start: 2024-07-05
• Primary Completion: 2025-04-15
• Study Completion: 2025-04-15

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Adult population between 30 and 75 years old.
• Unilateral painful thoracic herpetic eruption of less than one week duration.
• VAS more than or equal 4, persistent pain in spite of proper antiviral and analgesic therapy, (800 mg oral acyclovir, 5 times per day, for one week), pregabalin 300 mg per day, acetaminophen 1000 mg per day, topical calamine lotion).

Exclusion Criteria

• Diabetic patients.
• Painful herpetic eruptive vesicles more than one week.
• Abdominal herpetic eruptions.
• Non-compliant on anti-viral (bulbar palsy for example).
• Co-malignancy or radiotherapy.
• Steroid therapy > 5 mg prednisolone or its equivalent.
• Infections or hematoma at site of injection.
• Coagulopathy (chronic kidney or liver disease, clopidogrel use).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Erector spinae group	ultrasound guided erector spine block	800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)+ 25 ml bupivacaine 0.25% plus 8 mg dexamethasone
Serratus anterior group	Serratus anterior block	800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)+ 25 ml bupivacaine 0.25% plus 8 mg dexamethasone

Primary Outcome Measures

Name	Time	Method
pain score	immediate after injection, 1 week, 1, 3 months	Visual analogue scale from 0 to 10. 0= NO pain, 1-3=mild tolerable pain, 4-6= moderate pain, 7-10= severe untearable pain.

Secondary Outcome Measures

Name	Time	Method
analgesic consumption	1 week, 1, and 3 months	total amount dose of analgesics used
Number of patients with pain recurrence	1 week, 1, and 3 months	Number of patients in need for re-injection
Incidence of treatment related adverse events	immediately after injection	hypotension, bradyarrhythmia, hematoma