The ASPREE-Knee Sub-study: Does aspirin slow the progression of knee structural damage in adults over 70 years of age?

Phase 3

• Conditions: osteoarthritis; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12613000754741
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-07-05
• Study Completion: 2017-01-30
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 165

Inclusion Criteria

Randomised ASPREE participants in Melbourne (Age >=70 years, free of previous cardiovascular disease or stroke, have preserved intellectual function and have no known life-limiting illness)
Aged 70 and over
Able and willing to provide informed consent

Exclusion Criteria

1)As for ASPREE (Cardiovascular disease, impaired intellectual function, life limiting illness);
2)People with planned or prior knee joint replacement surgery of the dominant knee; unable to walk independently (no stick or frame).
3)People with rheumatoid arthritis, other inflammatory arthritis, or significant knee injury;
4)People undergoing arthroscopy or open surgery in the index knee in the last 12 months;
5)People receiving intra-articular therapy in the index knee in the last 12 months;
6)Any contraindication to MRI scanning (e.g. implanted pacemaker, metal sutures, presence of shrapnel or iron filings in the eye, or claustrophobia).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in knee cartilage volume, measured from MR images.[3 years. ]

Secondary Outcome Measures

Name	Time	Method
Knee symptoms (knee pain, stiffness and function and total) will be assessed using the WOMAC (the Western Ontario and McMaster Universities Osteoarthritis Index.[3 years, ];Gait speed: time taken in seconds to walk 3 meters at their usual walking pace from a standing start[3 years];Steps per day: using a pedometer (G-Sensor GS 2025) worn for 7 days at the waist. [3 years];Physical Activity: using the Physical Activity Scale in the Elderly questionnaire.[3 years]