the effects of oral rise with 0/2 and 2% chlorhexidine on oropharyngeal colonization and ventilator associated pneumonia
Not Applicable
- Conditions
- ventilator associated pneumonia.other acute lower respiratory infectionsJ20-J22
- Registration Number
- IRCT2015100624382N1
- Lead Sponsor
- Vice chancellor for research of Shiraz University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 112
Inclusion Criteria
18 years and older; informed consent; patients intubated and who on mechanical ventilation within 48 hours of admission; without a clinical diagnosis of pneumonia at the time of admission ; not to be pregnant ; without significant oral, facial trauma; not to readmitted to the ICU ; without known hypersensitivity to chlorhexidine; without an immunosuppression (disease or drug induced, e.g. organ transplant patient or those on long term steroid therapy); not to hospitalized for burn injury.
Exclusion criteria: aspiration; a diagnosed thrombocytopenia (platelet less than 40000); INR above 2 or other coagulopathy.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Oropharyngeal colonization. Timepoint: before intervention and if had exclusion criteria. Method of measurement: send culture and report semiquantitative.
- Secondary Outcome Measures
Name Time Method Ventilator associated pneumonia. Timepoint: before, during and until 48hours and if had exclusion criteria. Method of measurement: clinical pulmonary infection score and clinical diagnose and start new antibiotic by intensivist.